Endocrine Abstracts

Objective: To examine different methods of analysing bone health and body composition in children and examine the relationships between these methods.Method: In a LREC approved cross-sectional study, DXA was used to assess bone mineral content (BMC) (at total body (TB), lumbar spine (LS), femur (F) and femoral neck (FN)), cross-sectional moment of inertia (CSMI) at the proximal femur and body composition (defined as Lean mass (LM) and Fat mass (FM)) in 6...

G R Williams, Imperial College London, London, UK. AbstractGraham R Williams obtained a BSc in Anatomy and MBBS from St Thomas’s Hospital, London and undertook PhD studies in Molecular Endocrinology at Birmingham University. He trained as a Howard Hughes and MRC Fellow at Harvard Medical School, USA and was an MRC Clinician Scientist Fellow in Birmingham. He was appointed Senior Lecturer at the Royal Postgraduate...

Professor Jonathan R Seckl, UK AbstractThis prestigious prize is intended for established workers in the field of basic and clinical neuroendocrinology and is generously supported by Ipsen. This year’s recipient is Professor Jonathan R Seckl. The prize will be presented as part of the ICE/ECE 2012 opening ceremony where Prof. Seckl will deliver his lecture. Prof. Seckl will also deliver two other l...

E R Simpson, Prince Henry's Institute, Clayton, Victoria, Australia. AbstractDr Evan Simpson is a native of Edinburgh, Scotland. He has had a long interest in the basic biology of estrogen biosynthesis, especially its relationship to breast cancer.His group was the first to clone and characterize the aromatase gene and to show the unique use of tissue-specific promoters to regulate tissue-specif...

Aim: Differentiating idiopathic hypogonadotrophic hypogonadism from extreme maturational delay can be difficult, so most boys receive testosterone (T) replacement until the diagnosis becomes clear. Standard 3 month T therapy for maturational delay does not diminish adult stature, so we set out to determine whether T treatment of greater than 6 months duration would have an adverse effect on final height (FH) in boys with the eventual diagnosis of extreme maturational delay.</p...

Ligands have different binding affinities for mammalian and non-mammalian GnRH receptors. We have investigated whether this is due to differences in ligand contact sites and/or configuration of the receptors.The majority of residues that are contact sites in the mammalian receptor are conserved across species and are located in the extracellular loops (ECL's). The different binding affinities of ligands to non-mammalian receptors may be due to different ...

The incidence of cardiovascular diseases, diabetes mellitus and obesity is constantly growing in Latvia. Obesity in children is a globally progressing public health problem that can lead to serious metabolic abnormalities - insulin resistance and associated metabolic syndrome.Our objective was to determine the risk factors that contribute to the development of arterial hypertension in schoolchildren. 238 schoolboys between the ages of 7 and 19 were scree...

The incidence of cardiovascular diseases, diabetes mellitus and obesity is constantly growing in Latvia. Obesity in children is a globally progressing public health problem that can lead to serious metabolic abnormalities - insulin resistance and associated metabolic syndrome.Our objective was to determine the risk factors that contribute to the development of arterial hypertension in schoolchildren. 238 schoolboys between the ages of 7 and 19 were scree...

TESTOSTERONE-REPLACEMENT STIMULATED HYPERPROLACTINAEMIAR Sodi, R Fikri, M Diver, L Ranganath & J Vora*.Departments of Clinical Chemistry and Endocrinology*Royal Liverpool and Broadgreen University Hospital,Liverpool, UK. L7 8XP.Around half of all men with macroprolactinomas have hypogonadism and may require exogenous testosterone replacement. However, testoste...

Introduction: Over the last decade there has been a steady rise in obesity and co-morbidity, but little is known about the rate of metabolic dysfunction among young adults in the United Arab Emirates. Various factors have been implicated as biomarkers of metabolic syndrome (MetS). The objective of this study was to analyze the relationships of various biomarkers (leptin, C-reactive protein (CRP), adiponectin, insulin, and uric acid) to the MetS components in lean, overweight, ...